For Find in Files I like to keep in FIles: set to Current Project.
But occasionally 010 crashes–usually due to some glitch in a template of mine.
When that happens and I re-launch it, in Files reverts to some other setting. (I think it always changes to the directory path of the file most recently edited.)
I frequently Save All while editing, and though that saves a lot of editor settings to the config file, apparently these settings don’t get saved.